Harrisburg Ketamine Therapy

Ketamine Therapy near Harrisburg, PA

Makrides Aesthetics is now offering ketamine infusion therapy to the Harrisburg area. With ketamine therapy, Harrisburg area residents suffering from treatment-resistant depression and other debilitating mental health conditions can finally find relief. Ketamine infusion treatments, unlike other mental health medications, take effect almost immediately.


Founded by Dr. Lisa Makrides, a board-certified anesthesiologist and cosmetic physician, Makrides Aesthetics uses a personalized, evidence-based treatment approach to safely and effectively treat serious mental health conditions in our patients.

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How Does Ketamine Work?

Ketamine works in the body by targeting key receptor sites in the brain to protect against excitotoxicity and restore balance in how information is processed. Research has revealed how ketamine's effects go beyond acting on glutamate receptors; it also influences areas tied to motivation, emotion, and behavior, including monoamine transporters and opioid receptors, allowing it to target a wider array of symptoms quickly. Those seeking help managing their mental health condition can rest assured that ketamine is a safe and effective option to explore.

Find the relief you’ve desperately waited for with ketamine infusion therapy

Ketamine therapy has been used for decades to help treat individuals with serious mental health issues, including severe depression, mood disorders, and suicidal ideation.


Ketamine works in the body by targeting key opioid receptors in the brain, restoring balance in processing information. Unlike selective serotonin reuptake inhibitors (SSRIs), ketamine helps regrow and reactivate neural synapses, giving it a chance to emerge and heal from severe depressive states. 


Ketamine IV therapy can also be used for chronic pain management, bipolar disorder, post-traumatic stress disorder (PTSD), debilitating anxiety, and other mental health conditions, including addiction.

Our ketamine clinic near you in Harrisburg treats a variety of ailments

You can use ketamine treatments to treat a range of issues and it’s proven as a highly effective therapy for physical and mental health issues. In a time when mental health problems are on the rise, ketamine infusion shows a promising alternative for common disorders like depression, anxiety, addiction, and PTSD. Ketamine infusion therapy can also have positive impacts on other problems, such as chronic pain brought on by migraines or injuries.

  • Ketamine therapy for depression

    Ketamine for depression offers hope for those burdened with major depressive disorder that is resistant to other types of treatments. We administer measured doses of ketamine through IV infusion. Patients often feel significant improvement from major depression symptoms within minutes.

  • Ketamine therapy for anxiety

    Severe anxiety can make you feel like you're drowning. Ketamine treatments allow people suffering from anxiety disorders to slow down their brain and recover control over their thoughts so they can identify and address the root causes of their condition. Ketamine for anxiety is a safe, well-documented therapy that often treats anxiety more effectively than traditional pharmaceutical treatments.

  • Ketamine therapy for PTSD

    If you've been suffering from post-traumatic stress disorder (PTSD), ketamine can help you heal. A fast-acting and effective medication, ketamine is a well-documented therapy for PTSD symptoms. Even after a single dose, patients report increased psychological stability and decreased reliance on traditional antidepressants.

  • Ketamine therapy for addiction

    Recent studies have shown evidence that a series of low-dose ketamine infusions can block the symptoms of drug cravings and prevent relapse. Ketamine therapy is not appropriate for every patient with a history of substance abuse, so we tailor the treatment to each patient, working with them to build a plan that fits their condition and their needs.

  • Ketamine therapy for pain

    Ketamine infusion therapy targets chronic pain by blocking NMDA receptors, which can reduce pain signaling and improve neuroplasticity. If chronic pain has destroyed your quality of life, and traditional therapies or medications alone haven't worked for you, ketamine therapy might be the breakthrough you need.

“She is a gem! She shows so much empathy.”

“Dr. Makrides has been my pain management doctor for about 4 years. She is a gem! She shows so much empathy and will keep trying strategies until she finds one that will make your pain more manageable. She is extremely knowledgeable and up to date on all new alternatives. I highly recommend her!” —Linda T.

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Is ketamine therapy really going to work for me?

Ketamine therapy is not just another medication. It is an investment in your future. Ketamine infusion treatment has the potential to give you life-changing relief from mental health disorders and chronic pain. Many individuals have found ketamine for depression and anxiety to be particularly effective, offering rapid relief from symptoms.


As with any treatment, ketamine works differently for each person, which is why we personalize the treatment plan for every single one of our patients.

Will my ketamine treatment be covered by insurance?

Ketamine treatment is covered by some insurances and not others. Contact us, and we'll walk you through the level of coverage you'll get from your insurance and give you the information you need to make a confident decision about the costs and benefits of ketamine.


Get ketamine therapy near Harrisburg, PA →

Harrisburg’s trusted ketamine clinic

If you've tried other treatments and health care providers and nothing seems to help your mental health disorders or chronic pain, you have nothing to lose and everything to gain by trying ketamine infusion treatment.


Give Makrides Aesthetics a call today and we'll discuss whether ketamine therapy is right for you.

Just a short drive from all major locales in Dauphin County. Our office, conveniently located in Lititz, PA, is the first and only ketamine clinic within an hour's drive of the Harrisburg area:

  • Harrisburg
  • Hershey
  • Hummelstown
  • Londonerry
  • Swatara
  • Upper Paxton
  • Steelton
  • Middletown
  • Linglestown
Begin Your Road to Recovery Today!
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